9/26/22 VA NTC

Today we had a fantastic case presented by our amazing med/peds resident Dr. Uju Nwosu of an older male presenting with acute onset total body weakness and confusion. We started by considering diagnostic schemas for generalized weakness and acute encephalopathy. He had a history of metastatic cancer treated with immune checkpoint blockade and was found to be hypotensive with hyponatremia and low AM cortisol. Based on his presentation and further lab workup, we discussed a possible unifying etiology of immune check point-induced hypophysitis causing hyponatremia and secondary adrenal insufficiency. Thanks to Dr. Nwosu and our amazing clinical problem solvers for thinking through a fascinating case!

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