Grand Rounds 9/25 – Intrinsic and Extrinsic Regulation of Innate and Induced Tissue Mast Cells by Dr. Frank Austen

This morning, the inaugural Stephen Wasserman Lecture was given by Dr. Frank Austen. Dr. Austen began by recounting his experiences in the Stephen Wasserman lab where a cohort of post-docs and trainees then went to began their own prolific laboratories replicating the dynamic nature of the Wasserman lab.

Today’s presentation focused on highlighting the work that has led to the understanding of mast cell diversity and heterogeneity–work that has spanned several decades. Dr. Frank Austen highlighted several key studies that underscored differences in lineage development, variety of localization of mast cell progenitors and differences in granulation patterns of mature mast cells. Dr. Austen also highlighted that the hematopoietic lineage development of tissue mast cells is unique compared to other myeloid-derived cells because its early lineage progenitors have been found to leave the bone marrow to enter the circulation. These immature lineage mast cells immediately undergo transendothelial recruitment into peripheral tissues wherein the appearance of secretory granules with a particular protease phenotype is regulated by the peripheral tissue. Altogether these findings suggest dual roles of connective tissue mast cells (CTMCs) and mucosal mast cell (MMC) populations, based on distributions of where these populations reside within a tissue, dependence on T-cells, and lifespan.

Thank you to Dr. Austen for providing a fantastic overview of generations of work in this field and for a fantastic Grand Rounds presentation!

Alumni Shout Out! AHA Heart Walk


UCSD IM Residency alums Calvin Yeang, Kay Yeung, Ann Kuo, and future UCSD IM resident Nate (? Class of 2045?) walked to support heart health in the 2019 American Heart Association Heart Walk at beautiful Balboa Park today! Calvin (Cardiology) and Kay (Oncology) are 2014 graduates of our PSTP program and are now physician scientist faculty at UCSD. Ann is a 2015 grad of our categorical program and a former Chief Resident (2016); she is now practices Primary Care & leads the Survivorship program at Scripps Clinic Medical Group.

2018 Fellowship Match CONGRATULATIONS!

Dear UCSD Family, Please congratulate your fellow residents! We are fortunate to have had another AMAZING Fellowship match! We are SO PROUD of all of you!!!!!! And delighted to keep so many of you here with us at UCSD!! Sincerely, simerjot Allergy Jessica Galant-Swafford—UCSD Eric Jones—USC Amie Nguyen—Kaiser LA Hannah Wangberg–Scripps Clinic/Scripps Green Cardiology Prerana Bhatia—UCSD Quan Bui—UCSD Stephanie Koh—Baylor (Houston) Franz Schweis—Kaiser LA Endocrinology Preethika Ekanayake (2015 grad)–UCSD Alex Tyan—UCSD Geriatrics Shannon Devlin—UCSD Jean Guan—UCSD Gastroenterology Waseem Ahmad—UCSD Joe Meserve—UCSD Megan Reinders (2018 grad)–UCI  Fady Youssef–UCSD Hem/Onc Shiruyeh Schokrpur (PSTP)—UCSD David Xu—Fox Chase Cancer Center at Temple University  Infectious Disease Aaron Kofman (2017 grad)—Emory Sydney Ramirez (PSTP)—UCSD Pulmonary Critical Care Laura Barnes (2018 grad)—UCSD Sean DeWolf—UCSD Kevin Eng—UCLA Alex Pearce—UCSD Anand Srikrishnan—UT Southwestern


Residents, fellows, faculty and applicants from the Physician Scientist Training Program gathered together this morning for our Biannual Physician-Scientist Training Program Symposium. Presenters included Mary Lewinski, M.D., Ph.D, Assistant Professor of Medicine, Division of Infectious Diseases and Global Health (PSTP Trainee, 2008-2014). Dr. Lewinski spoke on her research and her path to her current position in a presentation entitled “Persistence:  Parallels in HIV-1 Counteraction of Antiviral Defenses and Academic Career Development.”  Aaron Miller, M.D., Ph.D., Assistant Professor of Medicine, Division of Hematology-Oncology (PSTP Trainee, 2010-2016) presented on “An HLA-agnostic Functional Neoantigen Discovery Platform.” JP Shen, M.D., Instructor, Division of Hematology-Oncology (PSTP Trainee, 2008-2014) spoke on his work “High-throughput Genetic Interaction Screens to Enable the Synthetic-lethal Approach to Precision Cancer Therapy.” Stay tuned for information about our Spring Symposium!